2011 December | Lymphatic Cancer

Archive for December, 2011

The Chronic and Acute Myelogenous Leukemia

Acute myelogenous leukemia (AML), as well called acute nonlymphocytic leukemia (ANLL), is a rapidly progressive neoplasm resulting from hematopoietic precursors, or myeloid stem tissue, that give rise to granulocytes, monocytes, erythrocytes, and platelets. There’s growing evidence that genetic events occurring early in stem mobile maturation can lead to leukemia. Very first, there’s a lag time of 5-10 years towards the development of leukemia after coverage to known causative agents such as chemotherapy, radiation, and particular solvents.

2nd, many instances of secondary leukemia evolve out of a prolonged “preleukemic phase” manifested like a myelodysplastic syndrome of hypoproduction with abnormal maturation without having precise malignant behavior. Finally, examination of precursor cells at a stage earlier than the malignant expanded clone in a provided kind of leukemia can reveal genetic abnormalities such as monosomy or trisomy of various chromosomes. In maintaining using the general molecular theme of neoplasia, extra genetic modifications are witnessed in the malignant clone compared with the morphologically normal stem cell that developmentally precedes it.

Acute myelocytic leukemias are classified by morphology and cytochemical staining. Auer rods are crystalline cytoplasmic inclusion bodies characteristic of, though not uniformly witnessed in, all myeloid leukemias. In contrast to mature myeloid tissue, leukemic cells have large immature nuclei with open chromatin and prominent nucleoli. The look from the individual kinds of AML mirrors the cell kind from which they derive. M1 leukemias originate from early myeloid precursors with no apparent maturation toward any terminal myeloid mobile type. This really is apparent within the lack of granules or other features that mark more mature myeloid cells. M3 leukemias are a neoplasm of promyelocytes, precursors of granulocytes, and M3 cells exhibit abundant azurophilic granules which are common of normal promyelocytes.

M4 leukemias arise from myeloid precursors that may differentiate into granulocytes or monocytes, whereas M5 leukemias derive from precursors currently committed towards the monocyte lineage. Therefore, M4 and M5 cells both include the feature folded nucleus and gray cytoplasm of monocytes, whereas M4 cells include also granules of the granulocytic cytochemical staining pattern. M6 and M7 leukemias can’t be readily identified on morphologic grounds, but immunostaining for erythrocytic proteins is positive in M6 tissue, and staining for platelet glycoproteins is apparent in M7 tissue.

Chromosomal deletions, duplications, and well balanced translocations had been noted about the leukemic tissue of some patients prior to the introduction of molecular genetic techniques. Cloning from the regions exactly where well balanced translocations occur has, in some cases, revealed a preserved translocation website that reproducibly fuses a single gene with an additional, producing in the manufacturing of a brand new blend protein. M3 leukemias show a really higher frequency of the t(15;17) translocation that juxtaposes the PML gene with the RAR- gene. RAR- encodes a retinoic acid steroid hormone receptor, and PML encodes a transcription factor whose target genes are unknown. The blend protein possesses novel biologic action that presumably results in improved proliferation and a obstruct of differentiation.

Interestingly, retinoic acid can induce a short-term remission of M3 leukemia, supporting the importance of the RAR–PML blend protein. Monosomy of chromosome seven can be observed in leukemias arising out from the preleukemic syndrome of myelodysplasia or in de novo leukemias, and in both instances this finding is associated with a worse clinical prognosis. This monosomy as well as other serial cytogenetic modifications may also be seen right after relapse of treated leukemia, a scenario characterized by a a lot more aggressive program and resistance to therapy.

As hematopoietic neoplasms, acute leukemias involve the bone marrow and usually manifest abnormal circulating leukemic (blast) cells. Occasionally, extramedullary leukemic infiltrates recognized as chloromas can be observed in other organs and mucosal surfaces. A marked improve within the number of circulating blasts can sometimes trigger vascular obstruction associated with hemorrhage and infarction within the cerebral and pulmonary vascular beds. This leukostasis results in symptoms such as strokes, retinal vein occlusion, and pulmonary infarction.

In most instances of AML along with other leukemias, peripheral blood counts of mature granulocytes, erythrocytes, and platelets are decreased. This is probably because of crowding from the bone marrow by blast tissue as nicely as the elaboration of inhibitory substances by leukemic cells or alteration of the bone marrow stromal microenvironment and cytokine milieu required for normal hematopoiesis. Susceptibility to infections consequently of depressed granulocyte amount and function and abnormal bleeding as a result of reduced platelet counts are common problems in sufferers initially presenting with leukemia.

Chronic myelogenous leukemia (CML) is an indolent leukemia manifested by an increased quantity of immature granulocytes in the marrow and peripheral circulation. One of the hallmarks of CML may be the Philadelphia chromosome, a cytogenetic function that is due to balanced translocation of chromosomes 9 and 22, producing in a fusion gene, bcr-abl, that encodes a kinase that phosphorylates a number of key proteins included in cell development and apoptosis. The fusion gene can recreate a CML-like syndrome when released into mice.

CML eventually transforms into acute leukemia (blast crisis), which is associated with further cytogenetic changes and a clinical course similar to that of acute leukemia. New courses of medicines that block the bcr-abl kinase by competing with the ATP-binding site, induce remissions in most patients in chronic phases of CML. Moreover, resistance to these bcr-abl inhibitors can include amplification from the bcr-abl breakpoint as nicely as the development (or clonal expansion) of mutations in the ATP-binding pocket of bcr-abl, which no longer allows binding of inhibitors.

Symptoms of Lymphoma in Women

in women are generally the same as for men.

Lymphoma often develops quietly and with few symptoms so it may take a while before you may realize that there is something very much the matter.

Following is a list of the typical symptoms of lymphoma in women and symptoms of lymphoma in men alike.

One thing to keep in mind is that these lymphoma symptoms can be symptoms of any of a large number of conditions that are generally harmless.

For this reason, it’s wise to consult with your doctor if you experience any of them.

1. Enlargement of the Lymph Nodes

This is the most characteristic lymphoma symptom and can be the only symptom that one experiences.

It’s very important to note that a lot of different things can cause an enlargement of the lymph nodes and it does NOT necessarily mean you have lymphoma!

Typically, the lymph nodes of the groin, armpit and neck will swell but cause no pain.

Humans have 500+ lymph nodes in the body which are basically “forts” of immunity.

When they swell, it is often indicative of the body initiating an immune response against some type of microscopic invader.

You may notice these lumps in the course of your daily routine, such as when showering or applying creams, etc.

The symptoms outlined most often only indicate a possible lymphoma if they are discovered in addition to swollen lymph nodes.

2. Losing Weight

Typically, sudden weight loss will occur over a period of several months with no good reason.

Weight loss can range from a few pounds to up to 20 or so.

3. Running a Fever

A random fever that keeps occurring for no good reason (i.e., is not connected with a flu, cold, etc.) is usually an indication to go see your physician.

Symptoms of lymphoma can be confused with symptoms of other illnesses and, in fact, a lymphoma that causes fever accompanied by lymph node swelling is frequently mistaken for a flu or something similar.

Additionally, in those afflicted by a Hodgkins type lymphoma, a quintessential type of fever termed Pel-Ebstein fever can develop.

4. Night Sweats

Excess sweating at night may find you waking up soaked in your own sweat.

5. Pruritis (Itchiness)

Lymphoma cells can secrete certain substance which cause the entire body to be itchy, a condition known as pruritis.

6. Lack of Appetite

Individuals with lymphoma can experience a drop in their usual appetite which can also cause weight loss, one of the other symptoms of lymphoma listed above.

7. Fatigue and Listlessness

Cancer cells hijack the body’s energy resource that would otherwise be utilized by healthy cells, causing a drop in energy levels.

8. Swelling

Depending upon where a lymphoma grows (and it can occur in any organ of the body), it may compress and block off veins, effectively limiting blood supply and causing swelling.

Site-specific lymphomas produce rather widely varying symptoms.

A lymphoma of the brain may cause pains in one’s legs while a lymphoma in the stomach can cause stomach pains.

General Symptoms of Lymphoma in Women and General Symptoms of Lymphoma in Men

The first and most obvious sign of lymphoma is adenopathy, aka lymphadenopathy, which is a painless swelling of the lymph nodes.

Swollen lymph nodes by themselves, however, are NOT necessarily an indication of lymphoma.

It requires medical testing to confirm or negate the diagnosis.

Symptoms of lymphoma can come in many varieties, dependent upon the location of the lymphoma, the stage of growth, size of tumor, etc.

Symptoms linked with bone marrow issues such as becoming anemic (having a low red blood cell count) are uncommon in the beginning stages of a lymphoma but often are seen later in the game and often as a result of treatment.

MALT (Mucosa-associated lymphoid tissue) lymphomas affect any mucosal site, the stomach being the most common one. Alterations in bowel movement and stomach pains can be indications.

As far as the stomach lymphoma goes, if it is a result of infection with the H. Pylori bacterium, antibiotic treatment can cause the lymphoma to regress in 70%+ of cases.

How To Report Your Symptoms To A Doctor Effectively:

Describe the intensity of your symptom on a scale such as “This hurts about a 7 out of 10?.

For visually observable symptoms, show them to the doctor and also explain how they started off and looked like initially.

Explain when you first experienced your symptoms

How long have you been experiencing this symptom?

Is the symptom constant or does it come and go?

Describe any medications or dietary supplements you take/did take starting from the time symptoms manifested.

Do the symptoms change depending upon body positioning, time of day, etc.?

Do certain foods trigger the symptoms?

Be as descriptive as possible. The more accurate and specific the information you give, the more your doctor will be able to pinpoint the nature of your problem (if you have any!) and the better he/she will be able to treat you and advise you.

As you can see the Symptoms of Lymphoma in Women are generally the same as they are for men. It’s important to pay attention to your body and note any symptoms you may have so that you can discuss them with your doctor in detail and he will be in a better position to help you.

John-Michael David is a well-informed patient who writes about the Symptoms of Lymphoma in Women and the Causes of Lymphoma among other important topics.

Perfect Pet Products Feline Leukemia Test at Home
publisher: Perfect Pet
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Pre-paid test at home kit for Feline Leukemia.Simply collect a small saliva or tear sample on the test strip, place in the pre-paid envelope, and mail to the testing lab.Test is performed within 24 hours with the results sent to you via e-mail, fax, or mail.Quick & Easy: Just moisten device with saliva or tear.Convenient: Mail sample to the veterinary lab.Rapid Results: Test is performed within 24 hours with the results sent to you via e-mail, fax, or mail.Accurate: Same accurate results as your veterinarian. Uses the same ELISA testing kit.Save Time & Stress: No need to make a stressful and time-consuming trip to the veterinarian.Save Money: No veterinarian office visit.

HealthScouter Lymphoma: Signs of Lymphoma and Symptoms of Lymphoma: Lymphoma Patient Advocate
publisher: Equity Press, published: 2009-08-14
ASIN: 1603321004
EAN: 9781603321006
sales rank: 6074078
price: $15.62 (new), $22.43 (used)

For the most honest, objective opinion, HealthScouter provides a patient’s view of the most common medical problems. Including hundreds of quotes, questions, and answers from patients themselves, this guide provides comprehensive information about a single condition for from perspective that matters: the patient’s perspective. Understand how current patients approach their medical challenges, and help overcome your own. This reference will help you see through obscure medical jargon and limited treatment options and empower you to better understand the issues that really matter: Diagnosis + Symptoms + What to Expect + Treatment Options + Medical Terminology

Childhood Hodgkin Lymphoma: Pediatric Cancer Guide to Symptoms, Diagnosis, Treatment, Prognosis, Clinical Trials (DVD-ROM)
by: Medical Ventures Press
publisher: Progressive Management, published: 2011-03-08
ASIN: 1422054187
EAN: 9781422054185
price: $19.95 (new)

This up-to-date and comprehensive DVD-ROM disc provides a superb collection of authoritative documents from the nation’s cancer experts on childhood childhood Hodgkin lymphoma: causes, signs and symptoms, diagnosis, lab tests, treatment and management options, and ongoing clinical research. Every aspect of this cancer is thoroughly covered. For patients, families, and caregivers, practical information is provided in clearly written patient education documents, with valuable tips and helpful advice. For medical professionals, doctor references and texts have detailed technical information and clinical background material. Over twenty major types of pediatric cancers and tumors are fully covered, giving you the information and resources you need, including sources of help and support. Childhood Hodgkin lymphoma is a disease in which malignant (cancer) cells form in the lymph system. There are two types of childhood Hodgkin lymphoma. Age, gender, and Epstein-Barr virus infection can affect the risk of developing childhood Hodgkin lymphoma. Possible signs of childhood Hodgkin lymphoma include swollen lymph nodes, fever, night sweats, and weight loss. Tests that examine the lymph system are used to detect (find) and diagnose childhood Hodgkin lymphoma. Certain factors affect prognosis (chance of recovery) and treatment options. Childhood Hodgkin lymphoma is one of the few pediatric malignancies that shares aspects of its biology and natural history with an adult cancer. When treatment approaches for children were modeled after those used for adults, substantial morbidities (primarily musculoskeletal growth inhibition) resulted from the unacceptably high radiation doses. Thus, new strategies utilizing chemotherapy and lower-dose radiation were developed. Approximately 90% to 95% of children with Hodgkin lymphoma can be cured, prompting increased attention to devising nonmorbid therapy for these patients. Contemporary treatment programs use a risk-adapted approach in which patients receive multiagent chemotherapy with or without low-dose involved-field irradiation. Prognostic factors used in determining chemotherapy intensity include stage, presence or absence of B symptoms and/or bulk disease. The option of omitting radiation following chemotherapy is only considered in patients achieving complete response to initial chemotherapy. Utilizing the huge capacity of the DVD-ROM disc, disease-specific coverage is supplemented with a comprehensive multimedia cancer and health encyclopedia, featuring hundreds of reports, guides and audio podcasts on a wide variety of cancer and health issues of critical importance to cancer patients. There is extensive coverage of the broad subject of cancer and its prevention and treatment (surgery, chemotherapy, radiation, advanced treatments, managing side effects). Documents and material from the National Cancer Institute (NCI), Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), National Institutes of Health (NIH), Environmental Protection Agency (EPA), Medline, Centers for Medicare and Medicaid Services (CMS), and Occupational Health and Safety Administration (OSHA) are included. Supplemental coverage includes: Clinical Trials Background Information, Workbook; In-Depth Program; Clinical Trials at NIH; How To Find A Cancer Treatment Trial; Taking Part in Cancer Treatment Research Studies; Access to Investigational Drugs; Taking Time: Support for People with Cancer; Facing Forward – Life After Cancer Treatment; When Someone You Love Is Being Treated For Cancer; Living Beyond Cancer: Finding a New Balance; Caring for the Caregiver; Young People With Cancer, A Handbook For Parents; When Cancer Returns; When Someone You Love Has Advanced Cancer / Support for Caregivers; Chemotherapy; Managing Chemotherapy Side Effects; Follow-up Care After Cancer Treatment, more.

Childhood Cancer Diagnosis – What Next?

There you stand, either in the pediatrician’s office or the emergency room, receiving the most horrific news imaginable that being the news that your child has a life threatening disease.

As most doctors do they tell you they are going to give you and your family a moment to digest what you have just been told. As you then look upon your child, who is looking up at you, confused and scared, you are hit with a barrage of questions. Why, how, and what next?

After the doctors have concluded the seemingly endless barrage of tests on your child, he/she and the rest of the medical staff give you the infamous “road map.” This road map is supposed to tell you how your child will be treated depending on their disease and the severity of said disease. Often this road map leaves you with more questions than answers.

Then your child is finally released from the hospital and sent home to await your next visit to the surgical room, infusion center, and clinic for labs or wherever your chemotherapy and/or radiation treatments are conducted. It is this down time that a familiar question comes floating back into your mind…. What next?

What next? Information gathering, entrust your child to the doctor, pray to God? It is imperative to learn as much about your child’s illness as possible. Learn the affects, side effects, pros and cons of each drug used. Do not be afraid to question everything the medical staff is doing. If it doesn’t make sense, ask for explanations, clarification and reconfirm with other medical staff. Do not overlook your parental instincts after all, you know your child the best and do not allow someone else to tell you otherwise. At first they may try to back you down or appease you and may even try to confuse you with medical jargon, but soon they will realize that you are not the kind of parent that sits on the sidelines and gives the doctors carte blanche in the faith and trust department. It is only through this vigilance that your child will receive the best treatment possible. You must be your child’s patient advocate.
2009 Conquering Cancer – The Empowered Patient’s Complete Reference to Childhood Cancer – Diagnosis, Treatment Options, Prognosis (Two CD-ROM Set)

This up-to-date and comprehensive set of two CD-ROM discs provides a superb collection of official Federal government documents on childhood cancer: signs and symptoms, diagnosis, lab tests, treatment and management options, and ongoing clinical research. Every aspect of the disease is thoroughly covered.

Tumors covered include: Brain Tumor (Brain Stem Glioma, Cerebellar Astrocytoma, Cerebral Astrocytoma, Ependymoma, Medulloblastoma, Supratentorial Primitive Neuroectodermal and Pineal Tumors, Visual Pathway and Hypothalamic Glioma, Other Brain Tumors); Ewing’s Sarcoma Family of Tumors; Germ Cell Tumor, Extracranial Hodgkin’s Disease; Leukemia; Leukemia, Acute Lymphoblastic; Leukemia, Acute Myeloid; Liver Cancer; Neuroblastoma; Non-Hodgkin’s Lymphoma; Osteosarcoma/Malignant Fibrous Histiocytoma of Bone; Retinoblastoma; Rhabdomyosarcoma; Soft Tissue Sarcoma; Unusual Childhood Cancers; Wilms’ Tumor and Other Childhood Kidney Tumors. For patients, practical information is provided in clearly written patient education documents. For medical professionals, doctor references and texts have detailed technical information and clinical background material.

Documents from the National Cancer Institute, Centers for Disease Control and Prevention (CDC), Food and Drug Administration (FDA), National Institutes of Health (NIH), Environmental Protection Agency (EPA), Medline, Centers for Medicare and Medicaid Services (CMS), and Occupational Health and Safety Administration (OSHA) are included. In addition to disease-specific information, there is extensive coverage of the broad subject of cancer and its prevention and treatment (surgery, chemotherapy, radiation, advanced treatments, managing side effects). There is no other reference that is as fast, convenient, and portable – everything you need to know, from the federal sources you trust.

Since navigating the Internet to find medical information can be confusing, our exclusive “Guide to Leading Medical Websites 2009″ has updated links to the 67 best sites! Weblinks let you quickly check for the latest clinical updates directly from the government and the best commercial portals, news sites, reference/textbook/non-commercial portals, and health organizations. Comprehensive cancer coverage includes: FDA Office of Oncology Drug Products, Oncology Tools – approved drugs, patient liaison * Dictionary of Cancer Terms (4000 items) * Division of Cancer Biology * Cancer Bulletin – archive of informative articles from NCI publication since 2004 * Cancers by Body Location, System * A-Z list of cancers * Clinical Trials * Complementary and Alternative Medicine * Coping – Complications and Side Effects – fatigue, pain, cardiopulmonary syndromes, cognitive disorders and delirium; fever, sweats, hot flashes; gastrointestinal complications, hypercalcemia; lymphedema; pruritus; sexuality and reproduction; sleep; nutrition; eating hints; emotions, anxiety, depression, adjustment, post-traumatic stress disorder; substance abuse; transitional care planning; radiation, home care, when cancer returns; Care for the Caregiver; Survivorship – end of life issues, advance directives, coping with advanced cancer, Hospice, Loss, Grief, and Bereavement * Division of Cancer Treatment and Diagnosis * Drug Development and Approval * Approved Oncology Drugs * Drug Dictionary – technical definitions and synonyms * Drug Information Summaries * Factsheets by cancer type, risk factors and possible causes, prevention, detection, diagnosis, therapy, support, coping, resources, tobacco and smoking cessation * Prevention, Genetics * Publications – specific cancers, treatment, trials, coping, testing, risks, nutrition * Screening and Testing * Support – organizations, finances and insurance * Chemotherapy, Radiation Therapy, Surgery, Cryosurgery, Laser, Hyperthermia, Targeted * Understanding Cancer

Fighting Leukemia With a Capsule

NTense is a food supplement which combines different powerful medicinal plants. The product became popular worldwide which led to the creation of a newer, more enhanced, version called N Tense-2. N Tense-2 is said to be an alternative cure for different types of cancer, including leukemia.

Components of NTense-2 proven to cure leukemia include Bitter melon, Espinheira Santa, Mullaca, Vassourinha and Cat’s Claws.

Bitter melon is a fruit-bearing vine. As its name suggests, bitter melon fruits are extremely bitter and are warty in appearance. Natives used the plant to cure measles and diabetes. Furthermore, it can be used to treat leprosy, eczema, sores and larger wounds. Taking in bitter melon also aids in eliminating parasites inside the body. Studies showed that all parts of the plant posses hypoglycemic properties which function to lower blood sugar beneficial for diabetics. Fruit extracts of bitter melon also aids in stabilizing insulin secretion and combined with the seeds, the fruit can eliminate excess fats in the body. Bitter melon has been considered clinically as a cure to diabetes mellitus only until further studies have revealed its possibility to cure leukemia, melanoma and liver cancer.

Espinheira Santa is a small tree that grows to five meters. It has green leaves and bears berries. Espinheira Santa fruits are oblong-shaped and contain one or two black seeds. The plant is often used to ease arthritis pain and extract of its leaves is taken in to cure stomach disorders such as ulcer and gastritis. Aside from leukemia, it can also inhibit tumor growths for adenocarcinoma, lymphoma and melanoma.

On the other hand, Mullaca is a shrub commonly used for treating hepatitis B and bacterial infections. It also aids in strengthening the immune system. Extraction of the whole plant can be used to cure leukemia. Components of the plant kills the cancer cells directly while at the same time enhancing the function of the immune system; thus, keeping the body active and healthy.

One of the most effective anti-cancerous plant ingredients of NTense-2 is Vassourinha. Vassourinha is an herb that grows only to half a meter high. It is commonly found in tropical countries and produces tiny, white flowers. Sadly, many people consider it as a weed.

Chemical tests conducted on vassourinha revealed that the plant contains many phytochemicals, some of which are only found in the plant. Vassourinha phytochemicals include scopadulcic acid and betulini acid exhibit antricancerous properties.

Scopadulcic acid can eliminate different kinds of cancer tumors while betulinic has shown anti-cancerous and antiviral potentials. The cytotoxic property of betulinic acid has been observed in melanomas and leukemia. Its curative effect on HIV is also currently being studied.

The cat’s claw herb is a common ingredient in traditional medicine. It is often used to treat inflammations and is said to be effective in correcting bone irregularities such as osteoporosis. In the field of women’s health, cat’s claws have been studied as possible treatment for breast cancer. Researches also showed that cat’s claw inhibited the mutation of some leukemia cells and killed the other damaged cells upon onset of application.

NTense-2 as a treatment for leukemia and other types of cancer is still under further study. However, seeing these plants and their curative properties, one cannot really question the high demand for NTense and the increasing market for NTense-2.

Cure of cancer chemotherapy is simple – effective or not?

According to statistics, cancer is in the top 5 of the things that most fear people. It is right up there with “Death” and that. It is also there are living with AIDS/HIV; but given that the acquisition of HIV or AIDS is pretty much always your fault, I is cancer… well, we say, you never know, who is gonna hit.

It is a silent epidemic, which affects everyone, because it respects no one. We all know people who have cancer, people looking for ways to cure cancer; and for many of us, unfortunately, the US and also love.

CHEMOTHERAPY
The most popular (and accepted) method of curing cancer is chemotherapy. Why? Because since we were small children we, that were taught we are sick, we go to the doctor. And here one more thing is we “learned”, the doctor is always right. Now, 99% of illnesses and diseases, they know exactly what they’re talking about. And also, if they are talking cancer, they know the why and how – to of the disease, cells, etc.. But it is about the healing of cancer, that’s where knowledge ends.

For starters, here is the dictionary definition:

Chemotherapy – the treatment of diseases through the use of chemicals, in particular for the treatment of cancer by cytotoxic and other drugs.

“Cytotoxic” means literally toxic for cells. This means that chemotherapy actually to kill your cells. Now, granted, they are targets the cancer cells, but here is the logic. Imagine a group of people, about one hundred of them collected in a small space. There are 5 of them, which must be eliminated. Now imagine thrown chemotherapy as a grenade into the crowd. Oh sure, you could kill the 5, but what happens with the 95?

Doctors can on this line of reasoning with me disagree, but it is what it is. You need to promote chemotherapy because now there is still no known methods or the perfect way of curing cancer. You have to kill toxic chemicals to the cancer patients, the cancer cells. The physician’s Hippocratic oath says “Do no harm.” Uhm, I think there are exceptions.

IF NOT THE CHEMOTHERAPY, THEN WHAT?
Common sense tells us that the way to life restoring life treatments and medicine. Why then are in the world we not that the methods for the treatment of cancer including?

The hospitals, doctors and even the Government promoted and recognised that chemotherapy is the only way to expand or extend the life of the patient; It is (sic) of the most scientifically accepted way of healing of cancer.

Believe me when I say, there are other solutions. Chemotherapy is basically – slow you kill during the killing of your disease (as sounds stupid, you know that?).

It’s time for a revolution. A healing revolution.

Research, research, and then some more research. Find out other healthy and life-giving way to restore your health, and other techniques of healing of cancer.

Be no fool. Accept not only what everyone is doing.

This is your life we’re talking about!

Cure of cancer is not impossible, with the one minute cure check it here why it is suppressed in the United States please follow this link for more information and also the high-performance 5-minute video presentation to see.

Lessons Learned From Cancer

Cancer is an insidious illness that touches way too many people. When faced with this disease, you basically have two choices: to go through the experience kicking and screaming or to learn and grow through the illness.

Cancer has taught me that I need to establish boundaries in my life. I learned to look out for my needs first, because without a healthy and strong mind and body, I cannot be at my best for anyone else.

Cancer has taught me that we should never take good health for granted. I used to be like so many other people when I said, “All I want is a healthy baby” or “Life is nothing without your health.” Of course, I meant it. But, I really didn’t understand the magnitude of these statements until my own struggles with cancer.

I’m a huge believer that the best physicians have a fine tuned sense of intuition. There are times when they just know they have to walk away from the data and follow their gut. But, even intuition has its basis in fact. If we, as patients, don’t take the time to tell our physician all the symptoms we are experiencing, he or she doesn’t have all the information they need to make a proper diagnosis.

I’ve learned that the human spirit is virulent. I am thrilled to see that many of our nation’s medical schools are now acknowledging the human spirit within their classrooms. They have learned that strong support systems, a good attitude, and prayer affect the overall survival of their patients. They are acknowledging that it is not just science, but also the human spirit, that can affect a patient’s future.

For years, alternative medicine – massage therapy, proper nutrition, chiropractic medicine – were not viewed as part of mainstream medicine. But, today, more and more physicians are beginning to understand their power. As such, students in medical schools across the country are learning about alternative medicine within their course curriculum. Oncologists will now put you in touch with nutritionists or send you to chiropractors to help ease your pain.

I’m amazed at how much more accommodating I am of grumpy people these days. Mainly, this is driven by the realization that I don’t know what’s going on in their personal lives. They might be waging their own battle against cancer. They may be struggling with a divorce, death, or a job loss. Having cancer has taught me to be more tolerant of people and to accept that they may be carrying a load of troubles on their back that we are unaware of.

Out of all of the lessons that cancer has taught me, the bottom line is this: we can all make our world a better place to live if we just lend a hand to others in need.

Sue Northey was diagnosed with Hodgkin’s Lymphoma in December of 1998. After undergoing both radiation and chemotherapy, she was deemed cancer-free in September 1999 and has remained in complete remission since.

Sue’s first book, Pilgrim Prayers for People Living with Cancer, was published in September 2004 by The Pilgrim Press. Her second book, On The Other Side: The Journey of a Cancer Survivor, was published in January 2007 by Whiskey Creek Press.

Sue has received two special awards that recognize her concerted efforts towards raising awareness and funds for cancer research. The Wisconsin Business Journal honored her as Milwaukee’s Woman of Influence in 2002 in the Inspirational Leader category and the Association for Women in Communications honored Sue as The Leading Change Business Leader in 2004.

Acute Leukemia Symptoms And What To Look For

Acute leukemia is a form of cancer that affects the white blood cells. It can present in many forms such as Acute Lymphocytic Leukemia (ALL), which is very common in children, especially 2-5 years of age; Acute Myelogenic Leukemia (AML), and Acute Non-Lymphatic Leukemia (ANLL). This article shares a brief overview of the symptoms to look for as well as the causes, diagnosis and treatment options associated with this disease.

Acute Leukemia

Symptoms – A man, woman or child with this condition may experience a constant tired feeling that can be accompanied with a low fever, anemia, pale skin, general ill feeling, easily bruised skin, and/or frequent nose bleeds or bleeding gums. Other possible symptoms include abdominal pain with an enlarged spleen, and infections with sores in the mouth.

Causes – The cause of this form of cancer is unknown, but risk of contracting the disease increases with a family history, Down Syndrome, or other congenital disorders, identical twins, or exposure to toxic chemicals.

Diagnosis – The first indication of a problem is typically an observation of the aforementioned symptoms. A physical exam with studies of the blood, bone marrow, or cerebral spinal fluid should follow to confirm the diagnosis. In some cases certain x-rays or CT scans may also be used to confirm the diagnosis.

Treatment – Proper treatment of acute leukemia may include blood or platelet transfusions, anticancer medication and radiation treatments. A bone marrow transplant may be necessary in some cases. A physician may also prescribe cortisone drugs and pain relievers (except aspirin) to help a patient deal with symptoms.

Acute leukemia is cancer of the white blood cells that can affect children and adults depending on the type of cancer. If treatment is successful and a patient goes into remission, there will be an ongoing need for check-ups to be certain it does not return.

Did you ever wish you had a simple tool that could walk you through your symptoms and lead you to an online diagnosis? Get a good idea of what your symptoms mean by simply answering yes or no using this Online Diagnostic Tool

21st Century Adult Cancer Sourcebook: Adult Acute Myeloid Leukemia (AML), ANLL, Myelogenous or Myeloblastic Leukemia – Clinical Data for Patients, Families, and Physicians

Authoritative information and practical advice from the nation’s cancer experts about acute myeloid leukemia (AML) includes official medical data on signs, symptoms, treatment options, drugs, chemotherapy, staging, biology, prognosis, and survival, with a complete glossary of technical medical terms and current references. Starting with the basics, and advancing to detailed patient-oriented and physician-quality information, this comprehensive in-depth compilation gives empowered patients, families, caregivers, nurses, and physicians the knowledge they need to understand the diagnosis and treatment of acute myeloid leukemia.

Adult acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated. It is the most common type of acute leukemia in adults. AML is also called acute myelogenous leukemia, acute myeloblastic leukemia, acute granulocytic leukemia, and acute nonlymphocytic leukemia. Normally, the bone marrow makes blood stem cells (immature cells) that develop into mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell. The lymphoid stem cell develops into a white blood cell. The myeloid stem cell develops into one of three types of mature blood cells: Red blood cells that carry oxygen and other materials to all tissues of the body; white blood cells that fight infection and disease; and platelets that help prevent bleeding by causing blood clots to form.

In AML, the myeloid stem cells usually develop into a type of immature white blood cell called myeloblasts (or myeloid blasts). The myeloblasts in AML are abnormal and do not become healthy white blood cells. Sometimes in AML, too many stem cells develop into abnormal red blood cells or platelets. These abnormal white blood cells, red blood cells, or platelets are also called leukemia cells or blasts. Leukemia cells can build up in the bone marrow and blood so there is less room for healthy white blood cells, red blood cells, and platelets. When this happens, infection, anemia, or easy bleeding may occur. The leukemia cells can spread outside the blood to other parts of the body, including the central nervous system (brain and spinal cord), skin, and gums.

Comprehensive data on clinical trials related to AML is included – with information on intervention, sponsor, gender, age group, trial phase, number of enrolled patients, funding source, study type, study design, NCT identification number and other IDs, first received date, start date, completion date, primary completion date, last updated date, last verified date, associated acronym, and outcome measures.

Extensive supplements, with chapters gathered from our Cancer Toolkit series and other reports, cover a broad range of cancer topics useful to cancer patients. This edition includes our exclusive Guide to Leading Medical Websites with updated links to 81 of the best sites for medical information, which let you quickly check for updates from the government and the best commercial portals, news sites, reference/textbook/non-commercial portals, and health organizations. Supplemental coverage includes:

Levels of Evidence for Cancer Treatment Studies
Glossary of Clinical Trial Terms
Clinical Trials Background Information and In-Depth Program
Clinical Trials at NIH
How To Find A Cancer Treatment Trial: A Ten-Step Guide
Taking Part in Cancer Treatment Research Studies
Access to Investigational Drugs
Clinical Trials Conducted by the National Cancer Institute’s Center for Cancer Research at the National Institutes of Health Clinical Center
Taking Time: Support for People with Cancer
Facing Forward – Life After Cancer Treatment
Chemotherapy and You

This is a privately authored news service and educational publication of Progressive Management.

Childhood Leukemia: A Practical Handbook (Pediatric Oncology)

This book is a comprehensive and up-to-date compendium on all aspects of childhood leukemia. After introductory chapters on the epidemiology and biology of pediatric leukemia, treatment considerations are extensively reviewed, with emphasis on the use of risk-adjusted treatment approaches. Promising targeted agents are discussed, and strategies for the development of new agents are appraised. The late effects of leukemia and its therapy are then considered in depth, with due attention to management of the psychosocial impact of the disease. Finally, global strategies to improve leukemia care and outcome are reviewed, and future directions discussed. The authors are internationally recognized experts and offer a largely evidence-based consensus on etiology, biology, and treatment. This handbook has far-reaching applicability to the clinical diagnosis and management of pediatric leukemia and will prove invaluable to specialists, generalists, and trainees alike.

Treatment of Acute Leukemias: New Directions for Clinical Research (Current Clinical Oncology)

International experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy.

Some Lymphatic Cancer Symptoms

Lymphatic cancer is a kind of cancer that affects the patient’s lymphatic cells. These are part of the immune system. Naturally, it is a serious medical condition. Someone that has this cancer may show lymphatic cancer symptoms. Do keep in mind, however, that a person could have this malignancy without displaying any of the symptoms mentioned here. Also, what you read on this page isn’t a complete list — nor is it, of course, intended to be used in place of advice from a doctor.

Anemia

The condition known as anemia may develop as one of the lymphatic cancer symptoms. While anemia can refer to multiple situations, in many cases it is an instance of fewer than normal red blood cells in the individual’s blood. This can medically occur in multiple ways: whether by a lack of sufficient production of them, by their destruction in high amounts, or by a the loss of a significantly high amount of blood. These, at least, are the three main ways in which it can occur.

Aside from lymphatic cancer, other medical causes of anemia are also possible. For instance, it may be due do a deficiency in vitamin B12. In this case, the condition is labeled as the pernicious form.

Shortness of breath

A person who has lymphoma may also experience breathlessness as a symptom. This is far from the only medical cause, however. Congestive heart failure is another possible reason. It can also occur in instances of chronic obstructive pulmonary disease, which is where chronic bronchitis and emphysema are present at once. Asthma is also a reason behind shortness of breath. Pneumonia and many other medical reasons can also be behind it. There are various diagnostic methods that can be used to look for or rule out possible causes, with a chest X-ray being one of the possibilities. There may be particular treatment methods that are aimed at this cause, if it is found.

Lymphatic cancer symptoms are more numerous than those contained on this page. Visit LymphomaSymptoms.org to read about more.

Clinical Lymphatic Mapping of Gynecologic Cancer
publisher: Informa Healthcare, published: 2004-08-12
ASIN: 1841842761
EAN: 9781841842769
sales rank: 4610629
price: $56.00 (new), $19.64 (used)

The first comprehensive text of lymphatic mapping in gynecological cancers, Clinical Lymphatic Mapping of Gynecologic Cancer, provides a historical perspective, an understanding of the associated modalities of pathology and diagnostic imaging, a disease site-specific review of the literature, and step-by-step descriptions of how to identify sentinel nodes. The text is fully illustrated, allowing readers to grasp the techniques as well as the analysis of the results. The editors address the entire breadth of the topic, making this an ideal reference source for newly qualified professionals and students in gynecological oncology.

Lymphatics in Cancer
by: C.D. Haagensen
publisher: W.B. Saunders Company, published: 1972-10-27
ASIN: 0721644430
EAN: 9780721644431
sales rank: 4227473
price: $129.95 (new), $31.96 (used)

The Lymphatic System and Cancer: Mechanisms and Clinical Management (Frontiers of Radiation Therapy and Oncology) (v. 28)
by: John L. Meyer
publisher: S Karger Pub, published: 1994-10
ASIN: 3805558899
EAN: 9783805558891
sales rank: 9011811
price: $278.00 (new), $75.88 (used)

We are entering a new era of understanding the lymphatic system based on important insights from experimental investigations and clinical trials. To achieve a cure, cancer therapies (whether by surgery, radiotherapy or systemic means) must be directed against the routes of cancer spread. The management of the regional lymphatic/lymph nodes, often the first site of involvement, is frequently a key decision in defining modern treatment programmes. Important new insights now challenge the basis of traditional cancer therapy recommendations. This volume brings together foremost authorities to outline the latest results in the management of the lymphatic system in cancer.

Lymphatic Metastasis and Sentinel Lymphonodectomy (Recent Results in Cancer Research)
publisher: Springer, published: 2000-06-15
ASIN: 3540666427
EAN: 9783540666424
sales rank: 7449150
price: $38.01 (new), $49.00 (used)

This volume gives a general summary of the current understanding of lymphatic metastasis and the possibilities of more specific detection of lymph node metastasis. It describes in detail the procedure of sentinel lymph node detection in urogenital tumors, neck and thyroid tumors, malignant melanoma, gastric and colorectal cancer and tumors of the breast. The potential and limitations of this new method are discussed. This book provides comprehensive insight into a both clinically and scientifically important new field which is bringing about a marked improvement in the treatment of malignant tumors.

Color Atlas of Surgical Anatomy for Esophageal Cancer
publisher: Springer, published: 1993-01-29
ASIN: 4431701001
EAN: 9784431701002
price: $220.50 (new), $213.22 (used)

It is essential to know all of the intricate lymph pathways when performing surgery for esophageal cancer in order to determine the extent of lymph node metastasis. Professor Sato has undertaken, at the request of the TNM Research Committee of the International Society for Diseases of the Esophagus, to map out and classify the lymph nodes of the mediastinum and neck. The beautiful artwork in the Color Atlas of Surgical Anatomy for Esophageal Cancer edited by Professor Sato gives an excellent understanding of the lymph node pathways and their importance in surgical treatment. Minute dissections which represent real life situations, not just the superficial pathways, show the precise location and topographical arrangement of the lymphatics. Full-color schematics are given with the actual dissection illustrations and photographs. The atlas clearly presents the classification of four significant pathways and their communication, the relationship of these pathways en route to the venous angles and the definition and assessment of the most critical nodes. Thoracic surgeons especially will benefit from the excellent illustrations of surgical techniques and the methods for recording the dissected lymph nodes which are presented by Professor Kakegawa. Leading experts fighting esophageal cancer with surgical treatment can use the classification in this outstanding atlas for many years to come as a standard for international comparison. The careful dissection of the lymph nodes may be the best way to improve survival rates after surgery for cancer of the thoracic esophagus.

Leukemia and Children

One of the most tragic of all forms of cancer is Leukemia, which each year kills thousands of children all over the planet. Leukemia is a disorder of the blood, the bone marrow, and the lymphatic system. as one would expect with a system of this size, complexity, and importance to the body, there are numerous ways that things can go wrong. Because of this, there are various types of leukemia, all with different areas of activity and effects on the body.

There are a few ways to breakdown which type of leukemia is being dealt with. There are divisions that could be made based on whether or not the patient is a child or adult, for example. But most commonly the division is made based on how the blood cells are effected, and where the abnormality is taking place.

With symptoms that mimic those of many other, milder illnesses, leukemia is a difficult disease to diagnose initially. Some of the symptoms one is likely to experience are pervasive feelings of fatigue, constant chills and night sweats, and susceptibility to infection. As you can see, these are all conditions that could come from something as mundane as being overworked and run down. Many people assume that’s exactly what the problem is, and don’t seek help until their condition becomes so bad that they are unable to perform normal everyday activities without extreme discomfort.

When a person does report to the doctor, a blood test or bone marrow test may be conducted. These are the only ways to reliably screen for leukemia. Because of the variousness of the symptoms, and the invasiveness of the screening methods, leukemia often goes undiagnosed, by some estimates in as many as 20% of all cases.

The classification of leukemia arises from a four-fold matrix of conditions. The first axis is that of acute vs. chronic. In the case of acute leukemia, large numbers of immature blood cells are rapidly released. Since they are not fully developed, they crowd out the productive cells, resulting in quick deterioration of health. In the chronic case, blood cells are more mature and build up more slowly, resulting in a gradual worsening of health.

The second axis of the matrix is that of lymphocytic vs. myelogenous. Lymphocytic leukemia effects the cells which make up the body’s immune system. Myelogenous leukemia effects the myeloid cells, which are responsible for producing the range of blood cells-white, red, platelet-in the body. This matrix yields four distinct forms of the disease, all of which have different degrees of danger and populations within which they occur.

Unlike some other forms of cancer, leukemia is not primarily caused by any lifestyle choices. There is a strong genetic component, which can be exacerbated by exposure to radioactive compounds. If you have a history of leukemia in your family it is important to stay vigilant and aware of your health. There are different treatments available and the earlier you can diagnose the problem (especially with the acute leukemia) the more likely you can survive.

The New Leukemia Drugs

While chemotherapy, radiation and surgery are well known cancer treatment methods, few people untouched by the malignant disease are aware of a new class of medication called targeted therapy drugs which are leading the way in a new, effective strategy in the war on cancer. Targeted therapy drugs are available for many different types of cancer but in the fight against leukemia, where surgery to remove a tumor is not an option, they are most welcome and improving survival rates.

Targeted therapy is a broad-based term used to describe a new class of drugs that seek to stop or inhibit the growth (dividing process) of new cancer cells by interfering with specific molecules that “signal” for new cancer cells to grow and develop. Since targeted therapy drugs are directed only at the molecules that “allow” the process of creating cancer cells, they generally do not harm healthy cells in the way that chemotherapy and radiation does, and is generally considered less harmful with side-effects than chemotherapy and radiation. Other names used to describe this class of drugs includes molecularly targeted drugs, and moleculary targeted therapies.

Targeted therapy drugs are used alone or in combination with chemotherapy drugs to maximize results. They are also divided up between first-line and second-line treatment consideration. First line treatment for cancer means that specific drugs, or a combination of drugs, is used in the initial round or course of treatment, before any other drug or combination of drugs is tried. Second-line treatment means that a specific drug, or combination of drugs, is used after first-round treatment was tried and failed, yielded poor results, produced side-effects considered too severe, and when a cancer has reappeared after remission.

Optimism over this new line of cancer drugs should be curbed since not all “targeted therapy drugs” turn out to be beneficial. Gemtuzumab ozogamicin (Mylortag®) was pulled from pharmacy shelves in the summer of 2010 by Pfizer after a closer look by the FDA revealed the drug offered no benefit when used with chemotherapy drugs, and after a greater number of deaths occurred in the group of patients who received Mylotarg compared with those receiving chemotherapy alone.

FIRST-LINE treatment targeted therapy drugs for leukemia include.

Imatinib (Gleevec®) is used to treat:

Philadelphia chromosome positive chronic myelogenous leukemia (CML).Hypereosinophilic syndrome or chronic eosinophilic leukemia (CEL).Relapsed or refractory Philadelphia chromosome positive acute lymphoblastic leukemia (ALL).

With this drug, more than 90% of patients will be able to keep CML in check for at least five years, reducing it to a chronic, manageable condition in that time. Gleevec is considered to be one of the most successful examples of targeted therapy, available today. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. Gleevec, approved in 2001, was one of the first targeted therapy drugs to come out and is one of the most widely used since it is also used to treat gastrointestinal stromal tumors (GISTS). Ninety percent of all chronic myelogenous leukemia cases involving the Philadelphia chromosome.

Nilotinib (Tasigna®) is used as a first line treatment to treat chronic myelogenous leukemia (CML) that is Philadelphia chromosome positive. Early results of an on-going 5 year study revealed in December, 2010, show that Tasigna might be superior to the popular Gleevec for treating CML patients. Tasigna cut the amount of a tell-tale protein in the blood in three times as many patients with leukemia as did it’s predecessor, Gleevec.

In a Bloomberg story stemming from press release issued by the drug’s maker, the company reported: “In the clinical trial, designed to follow about 900 patients for five years, almost three times more people taking 300 milligrams of Tasigna twice daily had only a trace amount of the Bcr-Abl protein in their blood after 24 months. The other patients took either 400 milligrams of Gleevec once a day or 400 milligrams of Tasigna twice a day.”

Tasigna is mabe by Novartis, the same company that created Gleevec. Novartis considers Tasigna the superior successor to Gleevec, whose patent runs out in 2015. The down-side of Tasigna is that it carries a black box warning from the FDA for an irregular heart rhythm (QT prolongation) that can lead to fainting, loss of consciousness, seizures, or sudden death. Even with this warning, the FDA granted Tasigna first-line treatment status for Philadelphia chromosome-positive chronic myeloid leukemia in the chronic phase in June, 2010.

Dasatinib (Sprycel®) was once the go to drug when Gleevec and other types of medications don’t work initially, no longer work, or are not administered due to their severe side-effects, but is now a first-line treatment drug for CML. Sprycel is used to treat:

Chronic myelogenous leukemia (CML). This includes patients with CML that is Philadelphia chromosome positive. (Approved first-line treatment).Acute lymphoblastic leukemia (ALL) that is Philadelphia chromosome positive, in patients who are not able to use other drugs including Gleevec. (Second-line treatment).

Sprycel works the same way as Gleevec, by blocking the action of an abnormal protein that tells cancer cells to multiply. Sprycel received first-line treatment status for CML-Philadelphia chromosome by the FDA in October, 2010.

SECOND-LINE treatment targeted therapy drugs for leukemia include:

Tretinoin (Vesanoid®) is used to treat acute promyelocytic leukemia in patients who did not benefit from other types of chemotherapy, or whose condition improved with other types of chemotherapy, but then got worse. Tretinoin is used to produce remission (a decrease or disappearance leukemia symptoms ) in APL, however, other medications must be used after treatment with tretinoin to prevent the cancer from returning. Vesanoid comes with an FDA warning for a group of symptoms related to its main ingredient which is a type of Vitamin A.

Rituximab (Rituxan®) is used in combination with other drugs (primarily the chemo drug fludarabine) to treat B-cell chronic lymphocytic leukemia, including hairy cell leukemia (a subtype of CLL). Rituxan comes with an FDA warning that oncologists make aware to their patients.

Alemtuzumab (Campath®) is used to treat B-cell chronic lymphocytic leukemia (B-CLL) after a chemotherapy drug called fludarabine has failed. Campath comes with an FDA warning that patients will be informed about.

Ofatumumab (Arzerra®) is approved by the Food and Drug Administration (FDA) to treat chronic lymphocytic leukemia (CLL) in adults that have not gotten better with a chemotherapy/targeted drug therapy involving fludarabine (chemo), and alemtuzumab (targeted).

Archive for December, 2011

The Chronic and Acute Myelogenous Leukemia

Recommended Reading

Symptoms of Lymphoma in Women

Recommended Reading

Childhood Cancer Diagnosis – What Next?

Recommended Reading

Fighting Leukemia With a Capsule

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Cure of cancer chemotherapy is simple – effective or not?

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Lessons Learned From Cancer

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Acute Leukemia Symptoms And What To Look For

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Some Lymphatic Cancer Symptoms

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Leukemia and Children

Recommended Reading

The New Leukemia Drugs

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